T8024
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T8024
Sigma
Tetrodotoxin
~99% (HPLC), powder
| Synonym: | Fugu poison, Maculotoxin, Tarichatoxin, TTX |
| CAS Number: | 4368-28-9 |
| Linear Formula: | C11H17N3O8 |
| Molecular Weight: | 319.27 |
| Beilstein Registry Number: | 49176 |
| EC Number: | 224-458-8 |
| MDL number: | MFCD00213719 |
| PubChem Substance ID: | 24900493 |
Description
| Biochem/physiol Actions | Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease. |
Properties
| assay | ~99% (HPLC) |
| form | powder |
| color | white |
| solubility | dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.) |
| strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.) | |
| Gene Information | rat ... Scnn1g(24768) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | IO1450000 |
References
| reference | Catterall, W.A., Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 20, 15-43, (1980) |
| Yoshida, S., Tetrodotoxin-resistant sodium channels. Cell. Mol. Neurobiol. 14, 227-244, (1994) | |
| Narahashi, T., et al., Recent advances in the study of mechanism of action of marine neurotoxins. Neurotoxicology 15, 545-554, (1994) | |
| Penzotti, J.L., Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. Biophys. J. 75, 2647, (1998) | |
| Taylor, C.P., and Narasimhan, L.S., Sodium channels and therapy of central nervous system diseases. Adv. Pharmacol. 39, 47-98, (1997) | |
| Merck | Merck 13,9318 |
| Beilstein | Beil. 27,IV,8206 |
